Polymyalgia Rheumatica

Posts Tagged ‘review’

Conclusions  The scarcity of randomized trials and the high level of heterogeneity of studies on PMR therapy do not allow firm conclusions to be drawn. However, PMR remission seems to be achieved with prednisone treatment at a dose of 15 mg/d in most patients, and reductions below 10 mg/d should preferably follow a tapering rate of less than 1 mg/mo. Methotrexate seems to exert glucocorticoid-sparing properties. (Source: Archives of Internal Medicine)
MedWorm: Polymyalgia Rheumatica

Source: Arch Internal Med
Area: News
A systematic review of the evidence on treatment of polymyalgia rheumatica concludes that there is a scarcity of controlled trials and significant heterogeneity in those that exist; as a result, it is not possible to draw firm conclusions on the optimum treatment.
 
Polymyalgia rheumatica (PMR) is a syndrome that occurs in people aged over 50 and presents with morning stiffness and aching in the shoulder and pelvic girdles, with signs of systemic inflammation. Systemic corticosteroids are the standard treatment, however there have been no systematic summaries of the evidence for corticosteroid or other therapy: the authors of this review aimed to determine whether there was evidence to indicate the optimum corticosteroid, dose, and dose reduct…

Authors: Spies CM, Cutolo M, Straub RH, Burmester GR, Buttgereit F
The circadian rhythm of symptoms in patients with chronic inflammatory diseases is well known. Circadian rhythms could be used to identify targets for time-adapted antiinflammatory therapies, which are administered prior to the flare of cytokine synthesis and inflammatory activity. In recent years, the diurnal variations in rheumatoid arthritis have been described precisely for pain, stiffness, and functional disability, as well as the underlying cyclic variations in hormone levels and cytokine concentrations. This review summarizes the current knowledge on circadian rhythms in other rheumatic diseases, focusing on polymyalgia rheumatica and ankylosing spondylitis.
PMID: 20360185 [PubMed - as supplied by publisher] …
MedWorm: Polymyalgia Rheumatica

Conclusion  We found overall valuable diagnostic performances for FDG PET against reference criteria. Standardized FDG uptake criteria
are needed to optimize these diagnostic performances.

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Giant cell arteritis of the female genital tract: report of a case and review of the literature.(Case Report): An article from: Southern Medical Journal

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Conclusions: This article reports 3 cases of AGEP related to administration of HCQ. HCQ-induced AGEP is a rare but severe, extensive, and acute reaction. No specific therapy is available, and correct diagnosis generally leads to spontaneous resolution once the causative drug has been withdrawn.
PMID: 18555940 [PubMed - in process] (Source: Clinical Therapeutics)

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We report 2 cases of crowned dens syndrome
masquerading respectively as meningitis and polymyalgia rheumatica, and review the literature with particular attention to
the clinical and radiological aspects of this under-recognised condition.

Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00296-009-1145-7Authors
Keith Siau, Musgrove Park Hospital Department of Rheumatology Taunton TA1-5DA UKMartin Lee, Royal Cornwall Hospital Department of Rheumatology Truro TR1-3LJ UKCatherine J. Laversuch, Musgrove Park Hospital Department of Rheumatology Taunton TA1-5DA UK

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